Wednesday, April 26, 2017

Why Microdosing Is Taking Over Medical Marijuana

Welcome to marijuana 2.0. With microdosing, people are getting the maximum benefit from the minimum amount, without becoming stoned, paranoid or lethargic. Some are microdsoing to regulate their moods, boost their creativity, or enhance their workouts and yoga sessions. Susannah Grossman, 29, founder of Verdant Communications in Denver, takes several small doses through the day. "It lifts my spirits, relieves the stress and tension that build up, and allows me to approach my work with more keen interest."

Michael Backes, author of Cannabis Pharmacy, says when prohibition ends, microdosing could be the most popular way that people use cannabis. Right now, however, anyone who wants to microdose faces two hurdles: finding the right minimum dose, and finding products that will deliver it.

The challenge with finding your dose is that it's different for each person. With most drugs, there's a bell curve. If you give two aspirin to 100 people, the majority will find it relieves pain, while some outliers may have negative reactions or need 8 pills to get relief. But with marijuana, there's no majority response.

One reason for this may be found in the way that cannabinoids – THC, CBD, and other compounds found in the plant – support the natural functioning of the endocannabinoid system, which can vary from person to person. Humans and other mammals have cannabinoid receptors, which are found throughout the body in tissues, organs, and especially the brain. The body naturally makes chemicals that fit into these receptors, and together they regulate and balance the body's systems, from digestion to nerve signaling to the immune system. Whether by coincidence or evolution, the cannabinoids found in the marijuana plant mimic the endocannabinoids made by the body.

Dustin Sulak, a physician and Reiki healer in Maine, has been practicing cannabis medicine since 2009. He says there are always forces, such as microbes and environmental toxins, pushing us away from balance, and other forces, such as the endocannabinoid system, bringing us back. "Our bodies are already working to prevent dementia, reduce inflammation, and respond to any pathological process," Sulak says. "If we can enhance the functioning of that system with a little bit of extra THC, we can benefit."

Sulak, 37, who wears his dark hair in a ponytail, has developed a protocol for microdosing. "I discovered that most people have a certain threshold of cannabis," Sulak says. "Below it they'll experience a gradual increase in health benefits, and above it they'll start building tolerance, experiencing diminishing benefits and more side effects, like short term memory loss and clumsiness." He adds, "I can't tell you your perfect dose, but I can teach you how to find it for yourself."

He describes the system. "Abstain from cannabis for two days. On day three, consume one milligram of THC and one milligram of CBD, preferably in a tincture or oil where they can be measured precisely. Before consuming, ask yourself three questions, and answer on a scale of one to 10: How easy is it to breathe, how comfortable and calm does your body feel and how easy is it for you to smile authentically, to feel content and grateful?"

After writing down your scores, he says, you take the cannabis, wait 45 minutes and ask the questions again. If there's been no change in your scores and you've felt no effect, increase the dose by one milligram.

"You repeat this process over the next few days," he says, "increasing the dose by small increments. When you reach a point where you feel a difference after consuming, you've found your minimal effective dose."

At this point, he asks patients to continue raising the dose by tiny amounts. At some point, he says, there will be no further benefit from a higher dose. "You've established your therapeutic range, and can take the minimum dose." (...)

Unlike many in the field, Sulak believes that THC is the primary health agent in marijuana. "The idea that THC is recreational and CBD is medical is far from true," he says. "THC, milligram for milligram, has a much greater therapeutic effect than CBD. You could treat pain with 3 mg of THC, but it might take 15 to 30 mg of CBD to attain the same relief." For overall wellbeing and to prevent disease, he recommends combining the two compounds.

by Sara Davidson, Rolling Stone | Read more:
Image: Getty